* The incidence of chronic inflammatory diseases, such as atopic dermatitis, hepatitis and pancreatitis, continues to rise.
* Chronic inflammation is a major risk factor for the development of cancer.
* Pancreatic cancer is among the most lethal malignancies, characterized by an extremely poor prognosis.

Chronic inflammation is a well-known promoting factor in cancer development. In particular, chronic inflammation associated with cancer creates an immunosuppressive environment characterized by the extensive infiltration of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). Addressing chronic inflammation in the tumor microenvironment is, therefore, a key factor in overcoming immunosuppressive tumors, such as pancreatic cancer.

Our laboratory is particularly interested in studying chronic inflammation in the pancreas and its role in cancer (eg, Pancreatic cancer), focusing on the interplay between cytotoxic T cells and immunosuppressive Tregs, etc. Currently, our research emphasizes:

• 1. The immune-metabolic regulation of immune cells in the tumor microenvironment.
• 2. Identifying tumor markers and drug candidates for cancer.
• 3. Finding the mechanism of underlying abnormal cell proliferation during cancer development.

These efforts aim to enhance our understanding of the immunosuppressive tumor microenvironment and identify potential therapeutic strategies.